Even if you don't play tower defense games, you've probably heard of Anime Adventures. Originally released in 2022, the game was closed due to technical issues but was re-released, almost a year later, just in time for the 2024 holidays, making it once again one of the Roblox experience is played by the most people.
AA is sometimes considered the epitome of a tower defense game with a strong progression system and units that you will no doubt be familiar with from your Anime Adventures experience.