Shortcuts Win + Shift + S in Windows 10, allows users to take a partial or full screen capture and copy it to the clipboard. In most cases, this feature works as expected, but sometimes it can also become unresponsive. If you face this problem, the following article from Quantrimang.com will help you.
Fix Windows + Shift + S shortcut not working
1. Clean the keys
Check to see if anything is stuck in the keys Win, Shift and S or not and physically clean the keys on the keyboard. Refer to the article: Instructions for self-cleaning the keyboard, cleaning the Laptop keyboard if you need help.
2. Turn on the Clipboard History toggle switch
Press the button Start and choose Settings.
Select the cell System > Sound and scroll down to find options Clipboard.
Click on it and in the right panel, see the toggle switch Clipboard History is enabled or not.

If not, move the switch to position On.
3. Check the Snip & Sketch toggle switch
Again, open Settingsselect the cell System and navigate to section Notifications & actions.

Here, make sure the toggle switch is on Snip & Sketch is placed in position On.
4. Reset Snip & Sketch
If the above methods do not bring the desired results, reset Snip & Sketch. To do this, go to Settings > Apps > Apps & features. Here, click Snip & Sketch.
You will see the link Advanced options appears below options. Click on it and press the button Reset in the next screen.

Additionally, you can uninstall and reinstall apps from the Microsoft Store. Go Settings > Apps > Apps & features and you will see the button Uninstall for Snip & Sketch. Go ahead and uninstall the app. Then go to Microsoft Store and reinstall the app.
5. Unplug and re-plug USB devices
Unplug and replug your USB devices like gamepads, etc. and see if that helps.
6. Use PrintScreen instead of Win + Shift + S
You can use keys instead PrintScreen instead Win + Shift + S.
To do so, press Win + I to open Settings > Ease of Access > Keyboardfind the option location Locate Use the PrtScrn button to open screen snippingthen enable the feature.
7. Fix problems in Clean Boot State
Third-party processes can also interfere with shortcut operation Windows + Shift + S. To identify the culprit, perform a Clean Boot and fix the problem manually as described in the article.
Wishing you success in troubleshooting!